Water → HCID 22993341, compound

Participants

Reaction Conditions

Reaction Steps

The compound obtained in Step C (1.5 g; 6.22 mmol) is suspended in 25 ml of water (4 ml/1 mmol). Potassium hydrogen carbonate (10 eq.; 62.2 mmol; 5.22 g), tetrabutylammonium bromide (0.05 eq.; 0.31 mmol; 100 mg) and bromoacetonitrile (8 eq.; 49.7 mmol; 3.46 ml) are then added. The mixture is stirred vigorously at 70° C. for 16 hours. After returning to ambient temperature, the product formed is extracted with dichloromethane. The organic phase is dried over MgSO4, filtered, and then concentrated under reduced pressure. The residue obtained is purified by flash chromatography on silica gel (eluant: PE/AcOEt (8/2)). The title product is obtained in the form of a solid.

Provenance & Evidence