Sodium Acetate → HCID 9862147, compound

Participants

Reaction Steps

The compound obtained in Step D (350 mg; 1.25 mmol) is dissolved in a Parr reactor with acetic anhydride. Raney nickel (30% by weight, 115 mg) and sodium acetate (1.5 eq.; 1.87 mmol; 154 mg) are then added. The mixture is left at 50° C. for 16 hours under a hydrogen pressure of 40 psi. After returning to ambient temperature, the solution is filtered over Celite and the filtrate is evaporated. The crude reaction product is purified by flash chromatography on silica gel (eluant: PE/AcOEt (1/9)). The title product is obtained in the form of white crystals and is recrystallised from an Et2O/i-PrOH (6/4) mixture.

Provenance & Evidence