Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylamine → N-ethyl-2-chloro-5-nitrobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylamine | HCID 6341 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Benzoyl chloride, 2-chloro-5-nitro- | HCID 117637 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-ethyl-2-chloro-5-nitrobenzamide | HCID 4380195 | 86% |
반응 단계
Alternatively, 2-chloro-5-nitrobenzoyl chloride (10 g, 45.5 mmol) in anhydrous dichloromethane (250 mL) with Amberlyst A-21 ion-exchange resin (17 g) was treated with a 2M THF solution of ethylamine (45 mL). The mixture was stirred at rt under nitrogen overnight. After filtration, the filtrate was concentrated to give N-ethyl-2-chloro-5-nitrobenzamide (9.0 g, 39 mmol, 86% yield) as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06620827B2 |
| 출처 데이터셋 | uspto-grants-2003_09 |
| ORD ID | ord-cf1ee053539145439223acb8c8f81aca |
| 출처 메모 | uspto-grants-2003_09 |