反应详情

After addition of 208 mg(1.0 mmol) of ethyl 2-(4-ethoxyphenyl)acetate to 0.2 ml(3.0 mmol) of chlorosulfuric acid dropwise at 0° C., the mixture was warmed to room temperature and stirred for one hour, and then poured into ice water. After the resultant was extracted with ethyl acetate, the extracted ethyl acetate solution was washed with water three times. The solvent was removed under reduced pressure to give 110 mg of the title compound in a yield of 34%.

1. extractionAfter the resultant was extracted with ethyl acetate
2. washthe extracted ethyl acetate solution was washed with water three times
3. customThe solvent was removed under reduced pressure