HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 10151608, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 2,6-Di-tert-butyl-4-methylphenol | HCID 31404 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | 2-bromo-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide | HCID 22993429 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10151608 | HCID 10151608 | — |
Reaction Steps
From 2-bromo-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide with tri-n-butyl-(3,6-dihydro-2H-pyrin-4-yl)-stannane, bis(triphenylphosphine)palladium(II) chloride, triphenylphosphine, lithium chloride and 2,6-di-tert-butyl-4-methylphenol in DMF. Then hydrogenation using palladium on charcoal in methanol and dichloromethane. ES-MS m/e (%): 477 (M+Na+, 16), 455 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06620811B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-9df9d99e56a14e95a8022f969214d57b |
| Source note | uspto-grants-2003_09 |