反应详情

温度

50 °C

A suspension of ethyl (R) 3-[4-(2-{4-[(2,3-dihydro-indole-1-carbonyl)-amino]-3-methoxy-phenyl}-acetylamino)-phenyl]-butyrate (1.3 g, Reference Example 4) in ethanol (40 mL) and water (15 mL) was treated with sodium hydroxide (5 mL, 1M). After stirring at 50° C. for 3 hours the mixture was evaporated to low bulk and then acidified with hydrochloric acid (1M). The resulting white precipitate was filtered, then washed with water, then with ether, and then dried to give the title compound (1.06 g) as a white powder. HPLC: RT=15.3 minutes (>95% by ELS). MS(ES+): 488(MH+); MS(ES−): 486(M−).

1. customwas evaporated to low bulk
2. filtrationThe resulting white precipitate was filtered
3. washwashed with water
4. dry with materialwith ether, and then dried