Sodium Hydroxide → HCID 22994060, compound

Participants

Reaction Steps

A solution of 267 mg (0.49 mmol) of 3-(3-t-butyloxycarboxy-aminophenyl)-5-[2-[(3,4,5-trimethoxyphenyl)amino]-4-amino-5-thiazolyl]-1,2,4-oxadiazole (prepared according to Example B(2)) in 3 mL of 50% trifluoroacetic acid in dichloromethane was stirred for 60 minutes at ambient temperature and then poured onto ice. 3N NaOH was added dropwise until the solution was basic, and the mixture was extracted with EtOAc. The organic layer was washed with NaHCO3 and brine, and dried over Na2SO4. The solvent was removed to yield 204 mg (95% yield) of the title compound as a light yellow solid.

Provenance & Evidence