HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-methylphenol → 4'-Hydroxy-3'-methyl-[1,1'-biphenyl]-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-methylphenol | HCID 16896 | — |
| Reactant | 4-Cyanophenylboronic acid | HCID 2734326 | — |
| Product | 4'-Hydroxy-3'-methyl-[1,1'-biphenyl]-4-carbonitrile | HCID 22274497 | 50% |
Reaction Steps
4-Cyanophenylboronic acid and 4-bromo-2-methylphenol were processed as described in Example 167A to provide the title compound (50% yield). 1HNMR (300 MHz, CDCl3) δ2.40 (s, 3H), 4.85 (bs, 1H), 6.83-7.65 (m, 7H); MS (CDI) m/z 210 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06620839B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-a21e063f503d43fea0013cda59fe3169 |
| Source note | uspto-grants-2003_09 |