3,4,5-Trimethoxybenzaldehyde → HCID 59094104, compound

Participants

Reaction Steps

A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-allyloxy-8-acetyl -3methylflavone (2.5 g, 0.0075 mol) and 3,4,5-trimethoxy-benzaldehyde (1.47 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.4 g of product m.p. 121-23° C., 1H-NMR (CDCl3)δ: 2.20 (s, 3H); 3.87 (m, 9H); 4.73 (d, 2H, J=5,1 Hz; 5.25-5.45 (m, 2H); 5.91-6.02 (m, 1H); 6.75 (s, 2H); 6.96 (d,1H, J=16 Hz); 7.10 (d, 1H, J=8.9 Hz); 7.30 (d, 1H, J=16 Hz); 7.42-7.46 (m, 3H); 7.55-7.59 (m, 2H); 8.34 (d, 1H, J=8.9 Hz).

Provenance & Evidence