Benzaldehyde → HCID 86587444, compound

Participants

Reaction Steps

A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-(prop-2-ynyloxy) -8-acetyl-3-methylflavone (2.49 g, 0.0075 mol) and benzaldehyde (0.8 g, 0.0075 mol) in ethanol 95%. The addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.8 g of product m.p. 157-59° C., 1H-NMR (CDCl3)δ: 2.20 (s, 3H); 2.56 (s, 1H); 4.86 (d, 2H, J=2.2 Hz); 7.05 (d, 1H, J=16 Hz); 7.23 (d, 1H, J=8.9 Hz); 7.31-7.50 (m, 7H); 7.50-7.57 (m, H); 8,34 (d, 1H, J=8.9 Hz).

Provenance & Evidence