Sodium Hydroxide → HCID 131724072, compound

HRID 1167962Notes

Reaction equation

[C:1]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([C:19]2[S:23][C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[C:20]=2[CH2:28][C:29]2[CH:34]=[CH:33][C:32]([O:35][CH2:36][CH2:37][N:38]3[CH2:42][CH2:41][CH2:40][CH2:39]3)=[CH:31][CH:30]=2)=[CH:15][C:10]=1[C:11]([O:13]C)=[O:12])([O:3]C)=[O:2].[OH-].[Na+:44]>>[Na+:44].[Na+:44].[C:1]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([C:19]2[S:23][C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[C:20]=2[CH2:28][C:29]2[CH:30]=[CH:31][C:32]([O:35][CH2:36][CH2:37][N:38]3[CH2:39][CH2:40][CH2:41][CH2:42]3)=[CH:33][CH:34]=2)=[CH:15][C:10]=1[C:11]([O-:13])=[O:12])([OH:3])=[O:2].[C:1]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([C:19]2[S:23][C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[C:20]=2[CH2:28][C:29]2[CH:30]=[CH:31][C:32]([O:35][CH2:36][CH2:37][N:38]3[CH2:39][CH2:40][CH2:41][CH2:42]3)=[CH:33][CH:34]=2)=[CH:15][C:10]=1[C:11]([O-:13])=[O:12])([OH:3])=[O:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 12087656HCID 12087656, compound

Product 1

HCID 131724072HCID 131724072, compoundYield 98%

Procedure

The title compound was prepared in 98% yield from methyl 2-(3-carbomethoxypropoxy)-5-[3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophen-2-yl]benzoate (Part A) by essentially following the procedure outlined in Example 1, Part D, (except using 2.0 equivalents of 1 N NaOH solution).

Sources & evidence

ORD record: ord-f2f6a0eb54e943c384069f6d5ec7d29e
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06620837B1

Reaction notes

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