HRID1167962

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：COC(=O)CCCOc1ccc(-c2sc3ccccc3c2Cc2ccc(OCCN3CCCC3)cc2)cc1C(=O)OC

HCID12087656

未命名化合物

PRODUCTS

生成物

结构：O=C(O)CCCOc1ccc(-c2sc3ccccc3c2Cc2ccc(OCCN3CCCC3)cc2)cc1C(=O)[O-].O=C(O)CCCOc1ccc(-c2sc3ccccc3c2Cc2ccc(OCCN3CCCC3)cc2)cc1C(=O)[O-].[Na+].[Na+]

HCID131724072

未命名化合物

收率 98%

PROCEDURE

实验过程

The title compound was prepared in 98% yield from methyl 2-(3-carbomethoxypropoxy)-5-[3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophen-2-yl]benzoate (Part A) by essentially following the procedure outlined in Example 1, Part D, (except using 2.0 equivalents of 1 N NaOH solution).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f2f6a0eb54e943c384069f6d5ec7d29e
来源数据集: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06620837B1
来源说明: uspto-grants-2003_09

反应 SMILES

[C:1]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([C:19]2[S:23][C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[C:20]=2[CH2:28][C:29]2[CH:34]=[CH:33][C:32]([O:35][CH2:36][CH2:37][N:38]3[CH2:42][CH2:41][CH2:40][CH2:39]3)=[CH:31][CH:30]=2)=[CH:15][C:10]=1[C:11]([O:13]C)=[O:12])([O:3]C)=[O:2].[OH-].[Na+:44]>>[Na+:44].[Na+:44].[C:1]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([C:19]2[S:23][C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[C:20]=2[CH2:28][C:29]2[CH:30]=[CH:31][C:32]([O:35][CH2:36][CH2:37][N:38]3[CH2:39][CH2:40][CH2:41][CH2:42]3)=[CH:33][CH:34]=2)=[CH:15][C:10]=1[C:11]([O-:13])=[O:12])([OH:3])=[O:2].[C:1]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([C:19]2[S:23][C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[C:20]=2[CH2:28][C:29]2[CH:30]=[CH:31][C:32]([O:35][CH2:36][CH2:37][N:38]3[CH2:39][CH2:40][CH2:41][CH2:42]3)=[CH:33][CH:34]=2)=[CH:15][C:10]=1[C:11]([O-:13])=[O:12])([OH:3])=[O:2]