Butanoic acid, 4-chloro-, methyl ester → HCID 131724072, compound

HRID 1167963Notes

Reaction equation

[Na+:1].N1(C[CH2:8][O:9][C:10]2[CH:18]=[CH:17][C:16]([C:19]3[S:23][C:22]4[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=4[C:20]=3[CH2:28][C:29]3[CH:34]=[CH:33][C:32]([O:35][CH2:36][CH2:37][N:38]4[CH2:42][CH2:41][CH2:40][CH2:39]4)=[CH:31][CH:30]=3)=[CH:15][C:11]=2[C:12]([O-:14])=[O:13])CCCC1.ClC[CH2:45][CH2:46][C:47]([O:49]C)=[O:48]>>[Na+:1].[Na+:1].[C:47]([CH2:46][CH2:45][CH2:8][O:9][C:10]1[CH:18]=[CH:17][C:16]([C:19]2[S:23][C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[C:20]=2[CH2:28][C:29]2[CH:30]=[CH:31][C:32]([O:35][CH2:36][CH2:37][N:38]3[CH2:42][CH2:41][CH2:40][CH2:39]3)=[CH:33][CH:34]=2)=[CH:15][C:11]=1[C:12]([O-:14])=[O:13])([OH:49])=[O:48].[C:47]([CH2:46][CH2:45][CH2:8][O:9][C:10]1[CH:18]=[CH:17][C:16]([C:19]2[S:23][C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[C:20]=2[CH2:28][C:29]2[CH:30]=[CH:31][C:32]([O:35][CH2:36][CH2:37][N:38]3[CH2:42][CH2:41][CH2:40][CH2:39]3)=[CH:33][CH:34]=2)=[CH:15][C:11]=1[C:12]([O-:14])=[O:13])([OH:49])=[O:48]

Participants

Reactant 2

HCID 76612Butanoic acid, 4-chloro-, methyl ester

HCID 23663891HCID 23663891, compound

Product 1

HCID 131724072HCID 131724072, compoundYield 54%

Procedure

The title compound was prepared in 54% yield by essentially following the procedures outlined in above in Example 1, Part A, from the phenol of Example 1, Part I, above, and methyl 4-chlorobutyrate.

Sources & evidence

ORD record: ord-3e428b5caa6e4901a8ad379493cbd1e0
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06620837B1

Reaction notes

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