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HRID1167985

反应详情

EQUATION

反应方程式

HRID 1167985 的结构方程式

REACTANTS

反应物

2
结构：Clc1nsnc1Cl
HCID79804

3,4-Dichloro-1,2,5-thiadiazole

C2Cl2N2S

结构：CCC[CH2][Sn]([CH2]CCC)([CH2]CCC)[c]1ccccc1
HCID607632

Stannane, tributylphenyl-

C18H32Sn

PRODUCTS

生成物

1
结构：Clc1nsnc1-c1ccccc1
HCID2764044

3-chloro-4-phenyl-1,2,5-thiadiazole

C8H5ClN2S

收率 48%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
催化剂HCID178418397

未命名化合物

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

1.9 g (0.00517 mol) of tributylphenyl stannane and 0.29 g (0.00025 mol) of tetrakis (triphenylphosphine)palladium(0) were added to a solution of 0.775 g (0.005 mol) of 3,4-dichloro-1,2,5-thiadiazole in 10 mL of toluene under nitrogen and heated at reflux. After 8 h, 0.145 g (1.25×10−4 mol) of tetrakis(triphenylphosphine)palladium(0) were added. After 24 h of reflux, 48% of product formed by quantitative HPLC (versus a reference prepared as reported by L. Weinstock et al., J. Org. Chem., vol. 32, p 2823 (1967)).

WORKUP

后处理

  1. temperatureheated
  2. temperatureat reflux
  3. temperatureAfter 24 h of reflux