Tert-butoxycarbonylalanine → t-butyl N-{2-[3-(acridin-9-yl)amino-5-(hydroxymethyl)anilino]-l-methyl-2-oxoethyl}carbamate

HRID 1167993노트

반응식

HRID 1167993 반응식
[CH:1]1[C:14]2[C:5](=[N:6][C:7]3[C:12]([C:13]=2[NH:15][C:16]2[CH:17]=[C:18]([CH:20]=[C:21]([CH2:23][OH:24])[CH:22]=2)[NH2:19])=[CH:11][CH:10]=[CH:9][CH:8]=3)[CH:4]=[CH:3][CH:2]=1.[C:25]([O:29][C:30]([NH:32][C@H:33]([C:35](O)=[O:36])[CH3:34])=[O:31])([CH3:28])([CH3:27])[CH3:26]>>[CH:1]1[C:14]2[C:5](=[N:6][C:7]3[C:12]([C:13]=2[NH:15][C:16]2[CH:17]=[C:18]([CH:20]=[C:21]([CH2:23][OH:24])[CH:22]=2)[NH:19][C:35](=[O:36])[CH:33]([NH:32][C:30](=[O:31])[O:29][C:25]([CH3:27])([CH3:26])[CH3:28])[CH3:34])=[CH:11][CH:10]=[CH:9][CH:8]=3)[CH:4]=[CH:3][CH:2]=1

참가 물질

3

반응물 2

HCID 85082Tert-butoxycarbonylalanineHCID 3804823-(9-Acridinylamino)-5-hydroxymethylaniline

생성물 1

HCID 22994836t-butyl N-{2-[3-(acridin-9-yl)amino-5-(hydroxymethyl)anilino]-l-methyl-2-oxoethyl}carbamate수율 77.2%

실험 절차

3-(9-acridinylamino)-5-(hydroxymethyl)aniline and t-butoxycarbonyl-L-alanine were reacted with the same method to the example 38 to give the titled compound.

출처 및 근거

ORD 기록
ord-12020acd7f9b4a3d80523702a856a832
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06620936B2

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