Sodium Carbonate → 2-((4S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethan-1-ol

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Reaction Steps

To a solution of (s)-1,2,4-butanetriol (0.842 g, 7.9 mmol) dissolved in acetone (12 ml) was added p-toluenesulfonic acid hydrate (20 mg) and the mixture was stirred for 21 hours at room temperature. Sodium carbonate (20 mg) was added to the mixture. After stirring for 1 hour, the mixture was filtered and condensed in vacuo to give (S)-4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane (1.023 g, yield 88%).

Provenance & Evidence