Potassium Carbonate → HCID 22991499, compound

Participants

Reaction Steps

In a flask equipped with a stirrer and a thermometer, 11.87 g of 2-(4-(trimethylsilylethynyl)-2-methylphenoxy)perhydro-2H-pyrane prepared in Step 2-2 and 0.13 g of potassium carbonate were suspended in 50 g of methanol under a nitrogen atmosphere, stirred at room temperature for 7 hours, and concentrated at 60° C. under a pressure of 20 Torr. The concentrate was purified through silica gel chromatography using a 20/1 (by volume) mixture of hexane/ethylacetate mixed with 0.1 wt % triethyl amine as an eluting solvent, to thereby obtain 8.10 g of 2-(4-ethynyl-2-methylphenoxy)perhydro-2H-pyrane at 91% yield.

Provenance & Evidence