Hydrochloric Acid → HCID 22483910, compound

Participants

Reaction Steps

To a stirred solution of 5.65 g m-aminophenol in 45m-acetonitrile was added dropwise 9.5 g benzenesulphonylisocyanate such that the temperature was maintained at <40° C. The mixture was stirred for one hour at room temperature and allowed to stand overnight. To the reaction was then added 25ml water and 5.35 g 47% caustic soda and the reaction was heated to 55-60° C. To this was added, over two hours, 9.93 g p-toluenesulphonylchloride with simultaneous addition of 47% caustic soda so as to maintain the pH between 10 and 11. After two hours at 60° C. the reaction mass was neutralised with hydrochloric acid to produce a thick white precipitate of the desired product. This was isolated by filtration and washed with water to give after drying 21.1 g of product, melting point 162-170° C.

Provenance & Evidence