HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiosemicarbazide → 4-Acetamido-3-iodobenzaldehyde thiosemicarbazone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiosemicarbazide | HCID 2723789 | — |
| Reactant | 4-Acetamido-3-iodobenzaldehyde | HCID 22991946 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | 4-Acetamido-3-iodobenzaldehyde thiosemicarbazone | HCID 3002296 | — |
Reaction Steps
Iodination of 4-aminobenzonitrile 30 with ICI produces 4-amino-3-iodobenzonitrile 31. Acetylatation of 4-amino-3-iodobenzonitrile 31 results in compound 32, which can be reduced with Raney nickel to form 4-acetamido-3-iodobenzaldehyde 33. Reaction of compound 33 with thiosemicarbazide yields 4-acetamido-3-iodobenzaldehyde thiosemicarbazone 34, as illustrated below.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06624153B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-580cd3150b984feaa4bf588641c3fa66 |
| Source note | uspto-grants-2003_09 |