HCID 470322, compound → 4-Aminosalicylic Acid

HRID 1168154Notes

Reaction equation

HRID 1168154 reaction equation
C([NH:4][C:5]1[CH:6]=[C:7]([OH:16])[C:8](=[CH:13][C:14]=1F)[C:9]([O:11]C)=[O:10])(=O)C.NC1C=C(O)C(=CC=1F)C(O)=O>>[NH2:4][C:5]1[CH:6]=[C:7]([OH:16])[C:8](=[CH:13][CH:14]=1)[C:9]([OH:11])=[O:10]

Participants

3

Reactant 2

HCID 470322HCID 470322, compoundHCID 470323HCID 470323, compound

Product 1

HCID 46494-Aminosalicylic Acid

Procedure

Table 8 shows the results of the preliminary screening tests of the prodrug, compound 11 and the fluorinated analog of PAS, 4-Amino-5-fluorosalicylic Acid 12.

Sources & evidence

ORD record
ord-97770a9d9eeb456cac635b22f449f211
Source dataset
uspto-grants-2003_09
Patent number
US06624153B2

Reaction notes

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