Propionyl chloride → HCID 10310563, compound

HRID 1168167Notes

Reaction equation

[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:13](=[O:22])[C:14]3[CH:19]=[CH:18][C:17]([CH2:20][NH2:21])=[CH:16][CH:15]=3)[S:11][C:7]=2[C:6]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)=[CH:5][CH:4]=1.[C:29](Cl)(=[O:32])[CH2:30][CH3:31]>>[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:13](=[O:22])[C:14]3[CH:19]=[CH:18][C:17]([CH2:20][NH:21][C:29](=[O:32])[CH2:30][CH3:31])=[CH:16][CH:15]=3)[S:11][C:7]=2[C:6]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 11280971HCID 11280971, compound

Product 1

HCID 10310563HCID 10310563, compound

Procedure

Using N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yi)-4-aminomethyl-benzamide and propionyl chloride, the title compound was prepared as off-white crystals (34% yield). MS: m/e=455(M+H+).

Sources & evidence

ORD record: ord-69effd0c502f4fa69647245fbeff6cb0
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06624163B2

Reaction notes

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