Propionyl chloride → HCID 10238906, compound

HRID 1168174Notes

Reaction equation

[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:13](=[O:24])[C:14]3[CH:19]=[CH:18][C:17]([CH2:20][NH:21][CH2:22][CH3:23])=[CH:16][CH:15]=3)[S:11][C:7]=2[C:6]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)=[CH:5][CH:4]=1.[C:31](Cl)(=[O:34])[CH2:32][CH3:33]>>[CH2:22]([N:21]([CH2:20][C:17]1[CH:18]=[CH:19][C:14]([C:13]([NH:12][C:10]2[S:11][C:7]3[C:6]([N:25]4[CH2:26][CH2:27][O:28][CH2:29][CH2:30]4)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=3[N:9]=2)=[O:24])=[CH:15][CH:16]=1)[C:31](=[O:34])[CH2:32][CH3:33])[CH3:23]

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 22992246HCID 22992246, compound

Product 1

HCID 10238906HCID 10238906, compound

Procedure

Using N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-4-ethylaminomethyl-benzamide and propionyl chloride, the title compound was prepared as white solid (47% yield). MS: m/e=483(M+H+).

Sources & evidence

ORD record: ord-c5f5f95d62c14f7396d63ade156a01dd
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06624163B2

Reaction notes

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