2-(Dimethylamino)acetyl chloride → HCID 10128248, compound

HRID 1168175Notes

Reaction equation

HRID 1168175 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:13](=[O:23])[C:14]3[CH:19]=[CH:18][C:17]([CH2:20][NH:21][CH3:22])=[CH:16][CH:15]=3)[S:11][C:7]=2[C:6]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)=[CH:5][CH:4]=1.[CH3:30][N:31]([CH2:33][C:34](Cl)=[O:35])[CH3:32]>>[CH3:30][N:31]([CH2:33][C:34]([N:21]([CH2:20][C:17]1[CH:16]=[CH:15][C:14]([C:13]([NH:12][C:10]2[S:11][C:7]3[C:6]([N:24]4[CH2:25][CH2:26][O:27][CH2:28][CH2:29]4)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=3[N:9]=2)=[O:23])=[CH:19][CH:18]=1)[CH3:22])=[O:35])[CH3:32]

Participants

3

Reactant 2

HCID 70103442-(Dimethylamino)acetyl chlorideHCID 10295168HCID 10295168, compound

Product 1

HCID 10128248HCID 10128248, compound

Procedure

Using N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-4-methylaminomethyl-benzamide and dimethylamino-acetyl chloride, the title compound was prepared as light yellow crystals (46% yield). MS: m/e=498(M+H+).

Sources & evidence

ORD record
ord-7b5008ee76c34f9f8ac4f78be8d13b3b
Source dataset
uspto-grants-2003_09
Patent number
US06624163B2

Reaction notes

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