2,4-Dichlorobenzylamine → 3-Chloro-4-(2,4-dichlorobenzylaminocarbonyl)-6-(4-pyridyl)pyridazine

HRID 1168181Notes

Reaction equation

HRID 1168181 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[CH:6][C:7]=1[C:8](Cl)=[O:9].[Cl:17][C:18]1[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][C:19]=1[CH2:20][NH2:21]>>[Cl:1][C:2]1[N:3]=[N:4][C:5]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[CH:6][C:7]=1[C:8]([NH:21][CH2:20][C:19]1[CH:22]=[CH:23][C:24]([Cl:26])=[CH:25][C:18]=1[Cl:17])=[O:9]

Participants

3

Reactant 2

HCID 14852,4-DichlorobenzylamineHCID 158952273-Chloro-4-chlorocarbonyl-6-(4-pyridyl)pyridazine

Product 1

HCID 120851053-Chloro-4-(2,4-dichlorobenzylaminocarbonyl)-6-(4-pyridyl)pyridazine

Procedure

The title compound was prepared by treating the dichloride (6) with 2,4-dichlorobenzylamine according to Scheme I. DCI-MS m/z 392 (m+H+). 1H NMR (CDCl3) δ 8.83 (d, J=6 Hz, 2H), 8.33 (a, 1H), 8.00 (d, J=6 Hz, 2H), 7.5 (m, 2H), 7.3 (m, 3H), 4.76 (d, J=6 Hz, 2H).

Sources & evidence

ORD record
ord-708db5e33ba24aaba43c0e6ef3415bf6
Source dataset
uspto-grants-2003_09
Patent number
US06624166B1

Reaction notes

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