HCID 10296995, compound → HCID 10138383, compound

Participants

Reaction Steps

A solution of 2-[(6-methoxypyrid-3-yl)methylamino]-N-[4-propynyl-3-(trifluoromethyl)phenyl]-3-pyridinecarboxamide (Example 30; 1.87 g, 4.25 mmol) in methanol (100 mL) is hydrogenated at atmospheric pressure over 5% platinum on carbon (0.4 g) at 22° C. The calculated amount of hydrogen is taken up in 13 hours. The mixture is then filtered and the solvent is evaporated off under reduced pressure to yield the crude product which is purified by recrystallisation from dichloromethane—hexane to give the title compound as a colourless crystalline solid, m.p. 51-61° C.

Provenance & Evidence