4-Aminomethyl-1-N-butylpiperidine → 5-Amino-n-[(1-butyl-4-piperidinyl)methyl]-6-chloro-2-ethylimidazo[1,2-a]pyridine-8-carboxamide

HRID 1168250Notes

Reaction equation

HRID 1168250 reaction equation
[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=[C:6]2[C:5]([C:13]([OH:15])=O)=[CH:4][C:3]=1[Cl:16].[CH2:17]([N:21]1[CH2:26][CH2:25][CH:24]([CH2:27][NH2:28])[CH2:23][CH2:22]1)[CH2:18][CH2:19][CH3:20]>>[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=[C:6]2[C:5]([C:13]([NH:28][CH2:27][CH:24]2[CH2:25][CH2:26][N:21]([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:22][CH2:23]2)=[O:15])=[CH:4][C:3]=1[Cl:16]

Participants

3

Reactant 2

HCID 104421334-Aminomethyl-1-N-butylpiperidineHCID 222364965-Amino-6-chloro-2-ethylimidazo[1,2-a]pyridine-8-carboxylic acid

Product 1

HCID 229922255-Amino-n-[(1-butyl-4-piperidinyl)methyl]-6-chloro-2-ethylimidazo[1,2-a]pyridine-8-carboxamide

Procedure

The title compound was prepared according to the procedure described in the step 3 of EXAMPLE 5 from 5-amino-6-chloro-2-ethylimidazo[1,2-a]pyridine-8-carboxylic acid (EXAMPLE 10, Step 2) and 1-(1-butyl-4-piperidinyl)methanamine (EXAMPLE 1, METHOD A, Step 5).

Sources & evidence

ORD record
ord-5b6eefa65dbb434cade6c700f7cf2e43
Source dataset
uspto-grants-2003_09
Patent number
US06624162B2

Reaction notes

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