4-Aminomethyl-1-N-butylpiperidine → 5-Amino-N-[(1-butyl-4-piperidinyl)methyl]-6-chloro-2-propylimidazo[1,2-a]pyridine-8-carboxamide

HRID 1168256Notes

Reaction equation

HRID 1168256 reaction equation
[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH2:12][CH3:13])[N:10]=[C:6]2[C:5]([C:14]([OH:16])=O)=[CH:4][C:3]=1[Cl:17].[CH2:18]([N:22]1[CH2:27][CH2:26][CH:25]([CH2:28][NH2:29])[CH2:24][CH2:23]1)[CH2:19][CH2:20][CH3:21]>>[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH2:12][CH3:13])[N:10]=[C:6]2[C:5]([C:14]([NH:29][CH2:28][CH:25]2[CH2:26][CH2:27][N:22]([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:23][CH2:24]2)=[O:16])=[CH:4][C:3]=1[Cl:17]

Participants

3

Reactant 2

HCID 104421334-Aminomethyl-1-N-butylpiperidineHCID 229922285-Amino-6-chloro-2-propylimidazo[1,2-a]pyridine-8-carboxylic acid

Product 1

HCID 229922185-Amino-N-[(1-butyl-4-piperidinyl)methyl]-6-chloro-2-propylimidazo[1,2-a]pyridine-8-carboxamide

Procedure

The title compound was prepared according to the procedure described in the step 3 in EXAMPLE 5 using 5-amino-6-chloro-2-propylimidazo[1,2-a]pyridine-8-carboxylic acid (EXAMPLE 16, Step 2) and 1-(1-butyl-4-piperidinyl)methanamine (EXAMPLE 1, METHOD A, Step 5).

Sources & evidence

ORD record
ord-af39b832ae164c51afe93435ce9b4077
Source dataset
uspto-grants-2003_09
Patent number
US06624162B2

Reaction notes

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