Phosphorus oxychloride → Ethyl 5-amino-2,6-dichloroimidazo[1,2-a]pyridine-8-carboxylate

Participants

Reaction Steps

A solution of ethyl 5-Amino-6-chloro-2-oxo-2,3-dihydroimidazo[1,2-a]pyridine-8-carboxylate (EXAMPLE 24, Step 2, 0.50 g, 2.00 mmol) in phosphorus oxychloride (4 mL) was refluxed for 4 h. After cooling, the mixture was evaporated. The obtained residue was carefully treated with water and 25% aqueous ammonia. The formed solid was collected by filtration to give 385 mg (72%) of the title compound.

Provenance & Evidence