4-Aminomethyl-1-N-butylpiperidine → 5-amino-N-[(1-butyl-4-piperidinyl)methyl]-2-chloroimidazo[1,2-a]pyridine-8-carboxamide

HRID 1168266Notes

Reaction equation

HRID 1168266 reaction equation
[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([Cl:11])[N:10]=[C:6]2[C:5]([C:12]([OH:14])=O)=[CH:4][C:3]=1Cl.[CH2:16]([N:20]1[CH2:25][CH2:24][CH:23]([CH2:26][NH2:27])[CH2:22][CH2:21]1)[CH2:17][CH2:18][CH3:19]>>[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([Cl:11])[N:10]=[C:6]2[C:5]([C:12]([NH:27][CH2:26][CH:23]2[CH2:24][CH2:25][N:20]([CH2:16][CH2:17][CH2:18][CH3:19])[CH2:21][CH2:22]2)=[O:14])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 104421334-Aminomethyl-1-N-butylpiperidineHCID 229922315-Amino-2,6-dichloroimidazo[1,2-a]pyridine-8-carboxylic acid

Product 1

HCID 229922095-amino-N-[(1-butyl-4-piperidinyl)methyl]-2-chloroimidazo[1,2-a]pyridine-8-carboxamide

Procedure

The title compound was prepared according to the procedure described in the step 3 in EXAMPLE 5 using 5-amino-2-chloroimidazo[1,2-a]pyridine-8-carboxylic acid (EXAMPLE 25, Step 3) and 1-(1-butyl-4-piperidinyl)methanamine (EXAMPLE 1, METHOD A, Step 5).

Sources & evidence

ORD record
ord-ef16053b01e4415b8ae68a0461a8e54d
Source dataset
uspto-grants-2003_09
Patent number
US06624162B2

Reaction notes

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