(2S,3R,4R,5S)-4,5-bis(acetyloxy)-2-(3-ethyl-5-isoxazolyl)tetrahydro-3-furanyl acetate → (2R,3R,4R,5S)-4-(Acetyloxy)-2-[6-[(2,2-diphenylethyl)amino]-2-({[2-(1-piperidinyl)ethyl]amino}carbonyl)-9H-purin-9-yl]-5-(3-ethyl-5-isoxazolyl)tetrahydro-3-furanyl acetate

Participants

Reaction Steps

Prepared by the same method as Preparation 27 from 6-[(2,2-diphenylethyl)amino]-N-[2-(1-piperidinyl)ethyl]-9H-purine-2-carboxamide (Preparation 11) and a mixture of (2S,3R,4R,5R)-4,5-bis(acetyloxy)-2-(3-ethyl-5-isoxazolyl)tetrahydro-3-furanyl acetate and (2S,3R,4R,5S)-4,5-bis(acetyloxy)-2-(3-ethyl-5-isoxazolyl)tetrahydro-3-furanyl acetate (WO-A-9967262).

Provenance & Evidence