HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-(acetylamino)-4-bromo-2-nitronaphtalene | HCID 348410 | — |
| Reactant | 4-bromo-2-nitronaphthalen-1-ol | HCID 11572534 | — |
| Product | Urea | HCID 1176 | — |
| Product | Naphth[1,2-d]oxazole | HCID 3718558 | — |
Reaction Steps
When 1-(acetylamino)-4-bromo-2-nitronaphtalene was treated with aqueous sodium hydroxide as described above the product was 4-bromo-2-nitro-1-naphtol—i.e. substitution occurred instead of hydrolysis. Subsequent hydrogenation and treatment with urea yielded naphto[1,2-d]oxazoline in 44% overall yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06624186B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-273143351a584cd59646ea5989288403 |
| Source note | uspto-grants-2003_09 |