Benzylamine → HCID 15574323, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-chloro-4-nitro-2,1,3-thiadiazole (1.0 g, 4.64 mmol) in anhydrous NMP (5 ml) was added triethylamine (0.65 ml, 4.64 mmol) and benzylamine (0.51 ml, 4.64 mmol). The mixture was heated to 80° C. for 1 hour. The cooled mixture was poured into ice-water (50 ml) and the product was filtered off, washed with water and dried. Yield: 1 g (75%). This product (0.5 g, 1.75 mmol) was suspended in ethanol (20 ml) and hydrogenated at ambient pressure using palladium (5% on activated carbon) as the catalyst. Yield: quantitative.

Provenance & Evidence