2-chloro-N-(4-fluorophenyl)acetamide → N-(4-Fluorophenyl)-N2-[3-methoxy-4-(5-oxazolyl)phenyl]glycinamide

Participants

Reaction Steps

A solution of 1D, (101 mg, 0.53 mmol) and 2-chloro-4′-fluoroacetanilide (50 mg, 0.27 mmol) in DMF (0.15 mL) was heated at 100° C. for 15 h. After the reaction had cooled, the solvent was removed under reduced pressure, and the residue was subjected to preparative HPLC to give 1 as a tan solid. LC/MS: ret. timeA32 3.527 min., MS (M+H)+=342.

Provenance & Evidence