反应详情

温度

130 °C

A mixture of diethyl 2-((2-(hydroxymethyl)-4-methylanilino)methylene)malonate (Preparation 24, 5.0 g) and acetic anhydride (5.0 mL) is heated at 130° C. for 1 h. The acetic anhydride is evaporated, and the residual solid is heated at reflux in diphenyl ether (20 ml) for 1 h. The solution is cooled and diluted with acetonitrile (5 mL) and ether (15 mL). The resulting precipitate is filtered to afford 1.8 g of the title compound.

1. customThe acetic anhydride is evaporated
2. temperaturethe residual solid is heated
3. temperatureat reflux in diphenyl ether (20 ml) for 1 h
4. temperatureThe solution is cooled
5. additiondiluted with acetonitrile (5 mL) and ether (15 mL)
6. filtrationThe resulting precipitate is filtered