HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 12083053, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Bromoacetic anhydride | HCID 4259817 | — |
| Reactant | HCID 178522895 | HCID 178522895 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 12083053 | HCID 12083053 | 77.2% |
Reaction Steps
Bromoacetic anhydride (40 mg) is added to a stirred solution of 8-((benzylamino)methyl)-N-(4-chlorobenzyl)-4-hydroxy-6-(4-morpholinylmethyl)-3-quinolinecarboxamide (Preparation 29, 53 mg) in NMP (0.3 mL). After 30 min, triethylamine (50 mg) is added. The solution is diluted with water and the resulting precipitate is filtered and dried under vacuum to give 44 mg of the title compound. Physical characteristics: HRMS m/z 571.2104 (C32H31ClN4O4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06624159B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-c2eff30fa81c4194a5a9e924dddf1432 |
| Source note | uspto-grants-2003_09 |