Benzoate → HCID 12112302, compound

HRID 1168545Notes

Reaction equation

HRID 1168545 reaction equation
[OH-].[K+].C([O-])(=O)C1C=CC=CC=1.[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([CH3:22])([CH3:21])[CH3:20])=[CH:15][C:14]=1/[C:23](/[CH3:36])=[CH:24]/[C:25]1[CH:35]=[CH:34][C:28]([C:29]([O:31]CC)=[O:30])=[CH:27][CH:26]=1>C(O)C>[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([CH3:22])([CH3:20])[CH3:21])=[CH:15][C:14]=1/[C:23](/[CH3:36])=[CH:24]/[C:25]1[CH:26]=[CH:27][C:28]([C:29]([OH:31])=[O:30])=[CH:34][CH:35]=1

Participants

5

Reactant 3

HCID 242BenzoateHCID 14797Potassium HydroxideHCID 12112301HCID 12112301, compound

Product 1

HCID 12112302HCID 12112302, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of potassium hydroxide in ethanol was added to 41 mg (0.12 mmol) of ethyl 4-[(E)-2-2-methyl-5-tert-butylphenyl)propen-1-yl]benzoate (Compound 26) and the resulting mixture stirred at room temperature. Solvent was removed in-vacuo and the resulting solid taken-up in water, acidified using 1N HCl, and extracted with ether. The ether extracts were washed with water, brine and dried (MgSO4). The solvent was removed in-vacuo to give the title compound as a yellow solid.

Workup

  1. customSolvent was removed in-vacuo
  2. extractionextracted with ether
  3. washThe ether extracts were washed with water, brine
  4. dry with materialdried (MgSO4)
  5. customThe solvent was removed in-vacuo

Sources & evidence

ORD record
ord-a065778e89034226af270174b4f66c30
Source dataset
uspto-grants-2003_09
Patent number
US06624188B1

Reaction notes

Loading…