2-Methoxyethanol → HCID 12112303, compound

HRID 1168548Notes

Reaction equation

HRID 1168548 reaction equation
[OH-].[Na+].COCCO.[CH3:8][C:9]1[CH:14]=[C:13]([C:15]([CH3:18])([CH3:17])[CH3:16])[CH:12]=[CH:11][C:10]=1/[C:19](/[CH3:32])=[CH:20]/[C:21]1[CH:31]=[CH:30][C:24]([C:25]([O:27]CC)=[O:26])=[CH:23][CH:22]=1>CCOCC>[CH3:8][C:9]1[CH:14]=[C:13]([C:15]([CH3:18])([CH3:16])[CH3:17])[CH:12]=[CH:11][C:10]=1/[C:19](/[CH3:32])=[CH:20]/[C:21]1[CH:22]=[CH:23][C:24]([C:25]([OH:27])=[O:26])=[CH:30][CH:31]=1

Participants

5

Reactant 3

HCID 80192-MethoxyethanolHCID 14798Sodium HydroxideHCID 22992377HCID 22992377, compound2×

Product 1

HCID 12112303HCID 12112303, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of sodium hydroxide, 2-methoxyethanol and ether was added to 70 mg (0.21 mmol) of ethyl 4-[(E)-2-(2-methyl-4-tert-butylphenyl)propen-1-yl]benzoate (Compound 28) and the resulting mixture stirred at room temperature for 5 hours. Solvent was removed in-vacuo and the resulting solid taken-up in water, acidified using 1N HCl, and extracted with ether. The ether extracts were washed with water, brine and dried (MgSO4). The solvent was removed in-vacuo to give the title compound as a yellow solid.

Workup

  1. customSolvent was removed in-vacuo
  2. extractionextracted with ether
  3. washThe ether extracts were washed with water, brine
  4. dry with materialdried (MgSO4)
  5. customThe solvent was removed in-vacuo

Sources & evidence

ORD record
ord-2d1a6e8944ad404fbf5ad18d892415db
Source dataset
uspto-grants-2003_09
Patent number
US06624188B1

Reaction notes

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