HCID 21348485, compound → HCID 22947700, compound

HRID 1168589Notes

Reaction equation

HRID 1168589 reaction equation
[Si:1]([O:18][CH2:19][C@H:20]1[O:24][C@@H:23]([N:25]2[CH:32]=[C:31]([CH3:33])[C:29](=[O:30])[N:28](COCC3C=CC=CC=3)[C:26]2=[O:27])[C@H:22]([O:43][CH2:44][CH2:45][OH:46])[C@@H:21]1[OH:47])([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd]>[Si:1]([O:18][CH2:19][C@H:20]1[O:24][C@@H:23]([N:25]2[CH:32]=[C:31]([CH3:33])[C:29](=[O:30])[NH:28][C:26]2=[O:27])[C@H:22]([O:43][CH2:44][CH2:45][OH:46])[C@@H:21]1[OH:47])([C:14]([CH3:16])([CH3:15])[CH3:17])([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 21348485HCID 21348485, compound

Product 1

HCID 22947700HCID 22947700, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

5′-O-t-Butyldiphenylsilyl-3-benzyloxymethyl-2′-O-(hydroxyethyl)-5-methyluridine prepared in Example 31 above is hydrogenated using 10% Pd on carbon as per the procedure of Example 35 above to give the title compound.

Sources & evidence

ORD record
ord-ce56b9c5627c4712bc3fe8bdc7c0dc71
Source dataset
uspto-grants-2003_09
Patent number
US06624294B2

Reaction notes

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