1,3-Dibromopropane → HCID 15550033, compound

Participants

Reaction Steps

A suspension of 500 mg (2.5 mmol) of Compound 13, 2.5 g (12.5 mmol) of 1,3-dibromopropane and 690 mg (5 mmol) of potassium carbonate in 25 ml of acetone was refluxed for 12 hours. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by chromatography on a silica gel column (eluent: ethyl acetate/methylene chloride =1/40), whereby 274 mg of the title compound were obtained (yield: 34%).

Provenance & Evidence