HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → HCID 73863355, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | p-Fluorophenyl 4-piperidyl ketone hydrochloride | HCID 3084438 | — |
| Reactant | HCID 73863353 | HCID 73863353 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 73863355 | HCID 73863355 | 95% |
Reaction Steps
A suspension of 112 mg (0.4 mmol) of Compound 20, 97 mg (0.4 mmol) of 4-(4-fluorobenzoyl)piperidine hydrochloride, 134 mg (1.6 mmol) of sodium hydrogencarbonate and 120 mg (0.8 mmol) of sodium iodide in 5 ml of acetonitrile was refluxed for 14 hours. Post treatment and purification were conducted as in Example 15, whereby 181 mg of the title compound were obtained (yield: 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06624314B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-cf711f1431fe4c508719ba5d3c283593 |
| Source note | uspto-grants-2003_09 |