Tetrahydrofuran → HCID 22992906, compound

Participants

Reaction Steps

4-Benzoylbenzoic acid (0.20 mmol) and the title B compound of example 1b (0.22 mmol) were dissolved in 1 mL of THF and triethylamine (0.22 mmol) and 4-dimethylamino-pyridine (0.02 mmol) were added. 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.6 ML, 0.15 M in dichloromethane, 0.24 mmol) was added and the mixture was allowed to stand for 48 hours. Purification by preparative HPLC (YMC ODS-A S% 30×250 mm column, 50-90% methanol water with 0.10% TFA gradient over 20 minutes, 25 ml/minute flow) provided 40 mg (61%) of a white solid. C21H23NO2: m/z=322 (M+H).

Provenance & Evidence