Triethylamine → HCID 12094482, compound

Participants

Reaction Steps

4-Acetylbenzoic acid (200 mg, 1.20 mmol) and amine 2 (from Example 1, 199 mg, 1.22 mmol) were dissolved in 5 mL of dichloromethane and triethylamine (187 μL, 1.34 mmol) and 4-dimethylaminopyridine (15 mg, 0.12 mmol) were added. 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (398 mg, 1.34 mmol) was added and the mixture was stirred for 18 hours. The reaction was diluted with ethyl acetate and washed with hydrochloric acid (1.0 M, aq.), sodium bicarbonate (sat'd., aq.) and sodium chloride (sat'd., aq.). The organic layer was dried over magnesium sulfate, filtered and the solvent removed to yield 216 mg (65%) of a white solid.

Provenance & Evidence