Cyclopentanecarboxylic acid, 2-oxo-, methyl ester → HCID 178517488, 화합물

HRID 1168676노트

반응식

HRID 1168676 반응식
O=[C:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[C:7]([O:9]C)=O.Cl.[Cl:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([NH2:19])=[NH:18])=[CH:15][CH:14]=1.CC(C)([O-])C.[K+]>CO>[Cl:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]2[N:18]=[C:7]([OH:9])[C:3]3[CH2:4][CH2:5][CH2:6][C:2]=3[N:19]=2)=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 66328Cyclopentanecarboxylic acid, 2-oxo-, methyl esterHCID 2034364-Chlorobenzene-1-carboximidamide hydrochlorideHCID 23665647Potassium tert-butoxide

생성물 1

HCID 178517488HCID 178517488, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

7.1 g of methyl 2-oxocyclopentane-1-carboxylate and 9.6 g of 4-chlorobenz-amidine hydrochloride were introduced into 50 ml of methanol. 5.6 g of potassium tert-butoxide were added with stirring. The reaction mixture was stirred under reflux for 4 hours and then poured onto ice water. The crystalline product was filtered off with suction, washed with water and recrystallized from dimethylformamide. Yield: 8.8 g. M.p.: 282° C.

후처리

  1. stirringThe reaction mixture was stirred
  2. temperatureunder reflux for 4 hours
  3. additionpoured onto ice water
  4. filtrationThe crystalline product was filtered off with suction
  5. washwashed with water
  6. customrecrystallized from dimethylformamide

출처 및 근거

ORD 기록
ord-267170297bd842ad87f0b6540e3e5d47
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06627628B1

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