Trifluoroacetic acid → HCID 69372777, compound

Participants

Reaction Steps

Prepared by lactonizing the intermediate product ((R)-4-[(3-chloro-4-fluorophenyl)amino]-6 ({4-[4-[N-(tert-butyloxycarbonylmethyl)-N-(2-hydroxypropyl)amino]piperidin-1-y]-1-oxo-2-buten-1-yl}amino)-7-cyclopropylmethoxyquinazoline, melting point: from 115° C. (with foaming); Rf value: 0.53 (silica gel, methylene chloride/methanol 9:1)) in the presence of 5 equivalents of trifluoroacetic acid in acetonitrile under reflux; melting point: from 126° C. (with foaming); mass spectrum (ESI+): m/z=623, 625 [M+H]+; Rf value: 0.29 (silica gel, ethyl acetate/methanol 4:1).

Provenance & Evidence