Acetic Anhydride → HCID 22185255, compound

HRID 1168729Notes

Reaction equation

HRID 1168729 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:8][C:9]1[CH:21]=[C:20]2[C:12]([C:13]3[CH:14]=[CH:15][N:16]=[CH:17][C:18]=3[N:19]2[NH:22][CH3:23])=[CH:11][CH:10]=1.[C:24](OC(=O)C)(=[O:26])[CH3:25]>N1C=CC=CC=1>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:8][C:9]1[CH:21]=[C:20]2[C:12]([C:13]3[CH:14]=[CH:15][N:16]=[CH:17][C:18]=3[N:19]2[N:22]([C:24](=[O:26])[CH3:25])[CH3:23])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 22185265HCID 22185265, compound

Product 1

HCID 22185255HCID 22185255, compoundYield 28.3%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of the product of example 43 (19 mg, 0.082 mmol) in pyridine (0.40 ml) was treated with acetic anhydride (0.037 ml, 0.36 mmol) in two portions over 48 h. The reaction was subsequently concentrated to dryness and the residue coevaporated with AcOH under reduced pressure. The crude product was purified as described in example 46. The pure fractions with product were combined and lyophilized to provide 9 mg of the title compound.

Workup

  1. concentrationThe reaction was subsequently concentrated to dryness
  2. customThe crude product was purified

Sources & evidence

ORD record
ord-26d61aa381634e3c92eab155d957de92
Source dataset
uspto-grants-2003_09
Patent number
US06627637B2

Reaction notes

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