Nitric Acid → HCID 178422973, compound

HRID 1168811Notes

Reaction equation

HRID 1168811 reaction equation
[N+:1]([O-:4])(O)=[O:2].[CH3:5][C:6]1[CH:15]=[C:14]2[C:9]([C:10]([OH:16])=[CH:11][CH:12]=[N:13]2)=[CH:8][CH:7]=1>C(O)(=O)CC>[CH3:5][C:6]1[CH:15]=[C:14]2[C:9]([C:10]([OH:16])=[C:11]([N+:1]([O-:4])=[O:2])[CH:12]=[N:13]2)=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 178422955HCID 178422955, compound

Product 1

HCID 178422973HCID 178422973, compound

Reagents, catalysts & solvents 1

HCID 1032Propionic AcidSolvent

Procedure

Nitric acid (6 mL of 70%) was slowly added to a hot (125° C. ) solution of 7-methyl-4-quinolinol (10.5 g) in propionic acid (125 mL). The reaction mixture was stirred for about 1.5 hours and then it was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, rinsed well with ethanol and water and then dried to provide 6.9 g of 7-methyl-3-nitro-4-quinolinol as a pale yellow solid.

Workup

  1. customThe resulting precipitate was isolated by filtration
  2. washrinsed well with ethanol and water
  3. customdried

Sources & evidence

ORD record
ord-a1971f1f061e44fc8d4ff3ada07a870f
Source dataset
uspto-grants-2003_09
Patent number
US06627640B2

Reaction notes

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