Carbon Dioxide → HCID 178516440, compound

HRID 1168817Notes

Reaction equation

HRID 1168817 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:15])=[C:7](C(O)=O)[CH:8]=[N:9]2)=[CH:4][CH:3]=1.C(=O)=O>>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:15])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 280Carbon Dioxide2×HCID 178524724HCID 178524724, compound2×

Product 1

HCID 178516440HCID 178516440, compoundYield 180.8%

Procedure

7-Fluoro4-hydroxy-3-quinolinecarboxylic acid (25 g) was placed in a round bottom flask and heated to 330-350° C. at which time carbon dioxide liberation commenced and the material began to liquefy. After about 2 minutes an additional 25 g of 7-fluoro-4-hydroxy-3-quinolinecarboxylic acid was added. The heating was continued for an additional 4 to 6 minutes at which time there was no further evolution of carbon dioxide. The solution was allowed to cool to ambient temperature. The resulting solid was isolated by filtration to provide 35.6 g of 7-fluoro4-quinolinol as a pink solid.

Workup

  1. customThe resulting solid was isolated by filtration

Sources & evidence

ORD record
ord-0fd13552e59449c3a7fdaf59dea82de5
Source dataset
uspto-grants-2003_09
Patent number
US06627640B2

Reaction notes

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