HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thyroxine → HCID 88038564, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thyroxine | HCID 5819 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Potassium bisulfate | HCID 516920 | — |
| Reactant | 2,5-Dioxopyrrolidin-1-yl 2-(trimethylsilyl)ethyl carbonate | HCID 5018386 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 88038564 | HCID 88038564 | — |
Reaction Steps
To a stirred suspension of thyroxine (1.66 g, 2.14 mmol) in DMSO (15 mL) was added triethylamine (3.21 mmol) followed by solid Teoc-0Su (610 mg, 2.35 mmol). The mixture was stirred at room temperature overnight then diluted with water (22 mL), acidified with saturated potassium hydrogen sulfate solution and extracted with ether (3×45 mL). The combined organic extracts were washed with water (4×45 mL), dried with magnesium sulfate, and evaporated to dryness. (Yield: 1.87 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06627660B1 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-853cf653229c4f04bebd2e7176412045 |
| Source note | uspto-grants-2003_09 |