反应详情

2.33 g of 4-(diphenylmethoxy)-1-piperidinepropaneamine and 714 mg of (6-chloro[1,2,4]triazolo[1,5-b]pyridazin-2-yl)carboxylic acid were stirred at 175° C. for 30 minutes. After cooling, the reaction mixture was crystallized by the addition of water-ethyl acetate-ethanol (2:2:1), collected by filtration, washed with water-ethyl acetate-ethyl ether (2:1:2) and dried to yield 598 mg of the title compound.

1. temperatureAfter cooling
2. customthe reaction mixture was crystallized by the addition of water-ethyl acetate-ethanol (2:2:1)
3. filtrationcollected by filtration
4. washwashed with water-ethyl acetate-ethyl ether (2:1:2)
5. customdried