Sulfuric Acid → 6-Chloro-[1,2,4]triazolo[1,5-b]pyridazine-2-carboxylic acid

HRID 1169118Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1169118
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:8]=[C:9]([CH3:11])[N:10]=2)[N:7]=1.S(=O)(=O)(O)O.[OH2:17].[OH2:18].[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[Na+].[Na+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:18])=[O:17])[N:10]=2)[N:7]=1

Komponenten

4

Edukt 3

HCID 1118Sulfuric AcidHCID 108005Sodium dichromate dihydrateHCID 122125266-Chloro-2-methyl-[1,2,4]triazolo[1,5-b]pyridazine

Produkt 1

HCID 229892926-Chloro-[1,2,4]triazolo[1,5-b]pyridazine-2-carboxylic acidAusbeute 82,7 %

Versuchsvorschrift

10.0 g of 6-chloro-2-methyl[1,2,4]triazolo[1,5-b]pyridazine was added to 55 ml of concentrated sulfuric acid under ice cooling conditions; 19.4 g of sodium dichromate dihydrate was added little by little at constant temperature, followed by stirring at room temperature for 4 days. Under ice cooling conditions, about 200 ml of ice water was added; the crystal precipitated was collected by filtration, washed with water and ethyl ether and dried to yield 9.74 g of the title compound.

Aufarbeitung

  1. customthe crystal precipitated
  2. filtrationwas collected by filtration
  3. washwashed with water and ethyl ether
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-75337b0a07104c1b9ed2bc66fe82f8f8
Quelldatensatz
uspto-grants-2003_09
Patentnummer
US06627630B1

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