HCID 9937786, compound → HCID 86759179, compound

HRID 1169150Notes

Reaction equation

HRID 1169150 reaction equation
[OH2:1].[OH2:2].[C:3]1([CH:9]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[O:10][CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][NH:20][C:21]3[CH:22]=[CH:23][C:24]4[N:25]([CH:27]=[C:28]([C:30]([CH3:35])([CH3:34])[C:31]([OH:33])=[O:32])[N:29]=4)[N:26]=3)[CH2:13][CH2:12]2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(O)C>[C:36]1([CH:9]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[O:10][CH:11]2[CH2:12][CH2:13][N:14]([CH2:17][CH2:18][CH2:19][NH:20][C:21]3[CH:22]=[CH:23][C:24]4[N:25]([CH:27]=[C:28]([C:30]([CH3:35])([CH3:34])[C:31]([O:33][C:34](=[O:2])[C:30]([CH3:35])([C:28]5[N:29]=[C:24]6[CH:23]=[CH:22][C:21]([NH:20][CH2:19][CH2:18][CH2:17][N:14]7[CH2:15][CH2:16][CH:11]([O:1][CH:9]([C:36]8[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=8)[C:3]8[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=8)[CH2:12][CH2:13]7)=[N:26][N:25]6[CH:27]=5)[CH3:31])=[O:32])[N:29]=4)[N:26]=3)[CH2:15][CH2:16]2)[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

Participants

3

Reactant 1

HCID 9937786HCID 9937786, compound

Product 1

HCID 86759179HCID 86759179, compoundYield 90.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 500 mL of ethanol, 3.20 g (5.67 mmol) of the 2-[6-[3-[4-(diphenylmethoxy)piperidino]propylamino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid dihydrate obtained in Example 135A was dissolved under heating, followed by concentrating at atomospheric pressure until the total volume became 250 mL. After standing at room temperature, the crystals formed were collected by filtration, washed with ethanol and dried to yield 2.67 g of the title compound.

Workup

  1. temperatureunder heating
  2. concentrationby concentrating at atomospheric pressure until the total volume
  3. customAfter standing at room temperature
  4. customthe crystals formed
  5. filtrationwere collected by filtration
  6. washwashed with ethanol
  7. customdried

Sources & evidence

ORD record
ord-95fa5a7e476d49df95001093df57e5dd
Source dataset
uspto-grants-2003_09
Patent number
US06627630B1

Reaction notes

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